Learn about the latest study findings from Linus Health

Sunday, July 16

Comparative Performance of the Digital Clock and Recall Test, Montreal Cognitive Assessment, and Saint Louis University Mental Status Among Patients in Primary Care

Lead author: Dustin B. Hammers, PhD
Indiana University School of Medicine, Department of Neurology

Location: P1-609

Key takeaways:

• Screening in primary care using the Linus DCR is feasible, and takes less time to administer than MoCA or SLUMS.
• DCR shows concordant results with both of these established screening tools in detecting cognitive impairment, with borderline impairment on the DCR corresponding to MoCA scores slightly below traditional cutoff, and impairment on the DCR corresponding to MoCA scores well below cutoffs.

Classifying Memory Clinic Patients Using the Digital Clock Drawing Test, Mini-Mental State Examination, and Philadelphia (repeatable) Verbal Learning Test

David Libon, PhD
Departments of Geriatrics, Gerontology, and Psychology, School of Osteopathic Medicine, New Jersey institute for Successful Aging, Rowan University

Location: P1-592

Key takeaways:

• DCTclock and verbal delayed recall measured by the Philadelphia (repeatable) Verbal Learning Test outperform the MMSE in differentiating among individuals with subtle cognitive impairment (SCI), amnestic mild cognitive impairment (aMCI), and mixed/dysexecutive MCI.
• These results show that a remote assessment battery including the DCTclock and a delayed recall task, that can be completed in a few minutes, can provide clinically meaningful insights that inform cognitive care.

Monday, July 17

Digital Cognitive Assessment Leveraging the Boston Process Approach Can Flag Emergent Cognitive Decline in Individuals with Subtle and Mild Functional Disability

David Libon, PhD
Departments of Geriatrics, Gerontology, and Psychology, School of Osteopathic Medicine, New Jersey institute for Successful Aging, Rowan University

Location: P2-1016

Key takeaways:

• Linus Health developed and engineered an iPad-administered digital Trail Making Test-Part B (dTMT-B) that yields numerous, novel process-based measures.
• DCTclock and dTMT-B metrics detected subtle and mild functional impairment in individuals with emergent cognitive decline.

Combined Digital Clock Drawing Test and Delayed Word Recall and their relationship with PET Amyloid Biomarker Status in Cognitively Unimpaired Older Adults

Ali Jannati, MD, PhD
Clinical Development Manager, Linus Health  

Location: Virtual Poster

Key takeaways:

• The DCR, which combines DCTclock with delayed verbal recall, can offer a means to classify amyloid-beta biomarker status among cognitively unimpaired individuals in as little as 3 minutes. 
• These results reinforce the potential of the DCR to streamline cognitive testing in the clinic and accelerate diagnosis for individuals with early-stage Alzheimer's and other dementias.

The Digital Clock Drawing Test and Delayed Recall Predict Informant-Rated Functional Impairment in Individuals with Cognitive Impairment

Ali Jannati, MD, PhD
Clinical Development Manager, Linus Health  

Location: Virtual Poster

Key takeaways:

• The DCR, brief digital cognitive assessments with automatic scoring that can be completed in primary-care settings can classify the patient's level of functional impairment within a few minutes. 
• This makes the DCR an empowering tool for primary-care providers in the practical evaluation of patients with cognitive impairment.

Prediction of Functional Dependence with Digital Clock Drawing, Word Recall, and Assessment of Lifestyle and Health Factors

Joyce Gomes-Osman, PhD, PT, ACE-CHC
VP, Clinical Development, Linus Health 

Location: P2-1028

Key takeaways:

• Distinguishing between MCI and early dementia requires assessing the clinical impact of cognitive deficits on a patient’s functional dependence in ADLs. Thus, to accurately evaluate patients at mid-to-late stages of MCI and early dementia, it is critical to combine cognitive screening with the assessment of functional impairment.
• Our results demonstrate that CCE and its two components, the DCR and the LHQ, are strongly associated with clinically relevant (mild and moderate) functional impairment. These results support the potential utility of the CCE to help to differentiate between individuals with MCI and early dementia in primary-care settings, streamline the clinical decision-making process, triage, and plan interventions for patients at later stages of MCI and earlier stages of dementia by primary-care providers.
  

Tuesday, July 18

A 10-minute Digitally Administered and Scored Neuropsychological Protocol Assessing Executive Control and Episodic Memory

David Libon, PhD
Departments of Geriatrics, Gerontology, and Psychology, School of Osteopathic Medicine, New Jersey institute for Successful Aging, Rowan University

Location: P3-850

Key takeaways:

• A 10-minute digital cognitive battery – that takes no longer than the MMSE or MoCA and can be administered remotely – detects impairments in executive control, language, and verbal episodic memory, thereby differentiating among cognitively unimpaired individuals, individuals with MCI, and those with probable dementia.
• This cognitive assessment battery can help streamline recruitment into ADRD trials, as well as promote more efficient healthcare delivery. 

The Electronic Person Specific Outcome Measure (ePSOM) Development Program in the US: A Survey to Understand What Matters to Individuals Most About Their Brain

Stina Saunders, PhD
Research Scientist, Linus Health

Location: P3-643

Key takeaways:

• Linus Health is developing a patient reported outcome (PRO) measure for use in adults with and without cognitive impairment.
• Our PRO tool monitors personally meaningful brain health priorities which are defined by the person’s own words (e.g., “Following a movie’s storyline” or “Being able to babysit my grandchildren on my own”).
• Linus Health is presenting preliminary results from a large-scale population-based study in the US collecting free text responses on what constitutes meaningful treatment outcomes.